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Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 549-561 doi: 10.1007/s11684-022-0965-7

Abstract: The type I interferon signature of pregnant patients with SLE was negatively correlated with the levelOur findings suggested that IgG influences lupus activity through regulating pDCs function<i> viai>

Keywords： pregnancy     IgG glycome     type I interferon     systemic lupus erythematosus    

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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract:

Superinfection is frequently detected among individuals infected by human immunodeficiency virus typeI (HIV-1).

Keywords： human immunodeficiency virus type I     superinfection     incidence     immune response    

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High-expression of recombinant human concensus interferon-α by Pichia pastoris

HAO Yuyou, SHI Qiqi, HE Yun, ZHUANG Yingping, WANG Yonghong, ZHANG Siliang, CHU Ju, LIU Zhimin

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4,   Pages 399-403 doi: 10.1007/s11705-007-0073-x

Abstract: The present work focused on the high expression of recombinant human consensus interferon- (cIFN) by

Keywords： bioactivity     pastoris     maximum     induction     optimized    

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Thermal and Mechanical Properties Optimization of <i>ABi>O4 Type EuNbO4 By the<i>Bi>-Site Substitution of Ta Article

Lin Chen, Jing Feng

Engineering 2020, Volume 6, Issue 2,   Pages 177-184 doi: 10.1016/j.eng.2019.12.006

Abstract:

Ferroelastic ABO4 type RETaO4 and RENbO4 ceramics (where

Keywords： Thermal barrier coatings     Rare earth niobates     Substitution     Thermal conductivity     Thermal expansion coefficients     Young’s modulus    

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Phase separation in cGAS-STING signaling

Frontiers of Medicine   Pages 855-866 doi: 10.1007/s11684-023-1026-6

Abstract: Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor immunity. At the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis. Interestingly, exciting recent studies have reported that biomolecular phase separation exists and plays important roles in different steps of cGAS-STING signaling, including cGAS condensates, STING condensates, and IRF3 condensates. In addition, several intracellular and extracellular factors have been proposed to modulate the condensates in cGAS-STING signaling. These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide new opportunities for drug discovery. Here, we summarize recent advances in the phase separation of cGAS-STING signaling and the development of potential drugs targeting these innate immune condensates.

Keywords： biomolecular condensates     phase separation     cGAS-STING pathway     cGAS     STING     cGAMP     interferon    

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New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 17-24 doi: 10.1007/s11684-021-0873-2

Abstract: Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threatening

Keywords： semaglutide     type 2 diabetes     obesity    

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Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 238-249 doi: 10.1007/s11684-017-0599-3

Abstract: The efficacy of salvage interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory

Keywords： interferon-α     hematopoietic stem cell transplantation     minimal residual disease     donor lymphocyte infusion    

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Personalized medicine of type 2 diabetes

Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 1-3 doi: 10.1007/s11684-013-0241-y

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Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 4-13 doi: 10.1007/s11684-013-0248-4

Abstract: current findings of metabolomic studies in human investigations with the most common form of diabetes, type

Keywords： metabolomics     type 2 diabetes     metabolic pathway     mass spectrometry     nuclear magnetic resonance (NMR)    

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Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 1071-1071 doi: 10.1007/s11709-021-0736-6

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The mechanisms linking adiposopathy to type 2 diabetes

Jichun Yang, Jihong Kang, Youfei Guan

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 433-444 doi: 10.1007/s11684-013-0288-9

Abstract: pancreatic β cell dysfunction and liver insulin resistance, which are the decisive factors causing typeregarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type

Keywords： obesity     adiposopathy     lipotoxicity     adipokines     diabetes    

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Mechanical performance analysis and stiffness test of a new type of suspension bridge

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5,   Pages 1160-1180 doi: 10.1007/s11709-021-0760-6

Abstract: A new type of suspension bridge is proposed based on the gravity stiffness principle.A new type of railway suspension bridge with a span of 340 m and a highway suspension bridge with a spanA stiffness test was carried out on the new type of suspension bridge with a small span, and the results

Keywords： new type of suspension bridge     stiffness test     mechanical performance     railway bridge     space truss    

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Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 427-437 doi: 10.1007/s11684-018-0672-6

Abstract: Desmoid-type fibromatosis (DF) is a rare monoclonal fibroblastic proliferation that is characterized

Keywords： targeted therapy     desmoid-type fibromatosis     tyrosine kinase inhibitor     γ-secretase inhibitor    

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Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

Frontiers in Energy 2009, Volume 3, Issue 4,   Pages 414-422 doi: 10.1007/s11708-009-0038-5

Abstract: An axial-type fan that operates at a relative total pressure of 671Pa and a static pressure ofPrior to the optimization of the fan blade, a three-dimensional axial-type fan blade is designed basedtests show that this optimization method can improve the efficiency and operating pressures on axial-type

Keywords： axial-type fan     gradient method     free-vortex method     design variable     total pressure     static pressure     operating    

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Low-temperature CO oxidation over Au-doped 13X-type zeolite catalysts: preparation and catalytic activity

Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG

Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 4,   Pages 497-504 doi: 10.1007/s11783-011-0256-z

Abstract: Au-supported 13X-type zeolite (Au/13X) was synthesized using a common deposition–precipitation (DP) methodA study was conducted on the effects of different preparation conditions (i.e., chloroauric acid concentration

Keywords： 13X-type zeolite     CO oxidation     gold solution     pH     calcination temperature    

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Title Author Date Type Operation

Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions

Journal Article

Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection:

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article

High-expression of recombinant human concensus interferon-α by Pichia pastoris

HAO Yuyou, SHI Qiqi, HE Yun, ZHUANG Yingping, WANG Yonghong, ZHANG Siliang, CHU Ju, LIU Zhimin

Journal Article

Thermal and Mechanical Properties Optimization of <i>ABi>O4 Type EuNbO4 By the<i>Bi>-Site Substitution of Ta

Lin Chen, Jing Feng

Journal Article

Phase separation in cGAS-STING signaling

Journal Article

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Journal Article

Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

Personalized medicine of type 2 diabetes

Weiping Jia

Journal Article

Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Correction to: Effect of wood dust type on mechanical properties, wear behavior, biodegradability, and

Journal Article

The mechanisms linking adiposopathy to type 2 diabetes

Jichun Yang, Jihong Kang, Youfei Guan

Journal Article

Mechanical performance analysis and stiffness test of a new type of suspension bridge

Journal Article

Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects

Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao

Journal Article

Development of an axial-type fan with an optimization method

Chong-hyun CHO, Soo-yong CHO, Chaesil KIM,

Journal Article

Low-temperature CO oxidation over Au-doped 13X-type zeolite catalysts: preparation and catalytic activity

Qing YE, Donghui LI, Jun ZHAO, Jiansheng ZHAO, Tianfang KANG, Shuiyuan CHENG

Journal Article